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Genes involved in the retinoic acid pathway, such as aldh1a2, crabp1, crabp2, rarg , and cyp26c1 , exhibited altered expression, suggesting a disruption in retinoic acid synthesis and signaling ( Animal models have identified the impact of flavored e-cigarette use on several pathways, including those associated with the immune system, oxidative stress, and DNA damage, among others

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For example, some e-cigarette flavorings may be safe to eat but not to inhale because the gut can process more substances than the lungs